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Usual Adult Dose for Congestive Heart Failure. ondansetron hcl 4 mg obat apa Initial dose: 25 mg orally three times a day (6 25 to 12 5 mg orally three times a day if hypotensive, hyponatremic, or hypovolemic) Target maintenance dose: 50 mg orally three times a day for at least two weeks to ensure a satisfactory response Maximum dose: 450 mg/day